西北师范大学林奇团队报道了柱[5]芳烃和氮衍生物组装改进的CN^–双通道检测。相关研究成果于2024年6月10日发表于国际一流学术期刊《中国化学》。

氰化物阴离子（CN^–）是已知毒性最强的阴离子之一。因此，迫切需要开发一种可靠、灵敏、选择性、快速有效的检测CN^-的方法。

该文采用基于柱[5]芳烃P5和嗪衍生物AZ的自组装策略构建超分子传感器，改组装策略显著提高了CN^–的检测效果。组装的传感器P5-AZ对CN^–的灵敏度是AZ的10倍以上。通过理论计算和¹H NMR进一步研究了检测机制。结果表明，AZ通过荧光增强的去质子化过程检测CN^–，而P5-AZ通过氢键、阴离子-π和阴离子-偶极相互作用提高了CN^–识别的灵敏度，以及组件的强结合能力。

超分子组装P5-AZ具有低毒、高灵敏度的优点，更重要的是，它提供了一种通过主客体组装检测水相和生物体中CN^-敏感性的方法。

附：英文原文

Title: Pillar[5]arene and Azine Derivative Assembly Improved Dual-Channel Detection of CN–

Author: Qing-Ling Su, Jin-Fa Chen, Xiao-Mei Sun, Juan Liu, Xin-Yu Dai, Tai-Bao Wei, Hong Yao, Qi Lin

Issue&Volume: 2024-06-10

Abstract: The cyanide anion (CN–) is known to be one of the most toxic anions. Therefore, there is an urgent need to develop a reliable, sensitive, selective, rapid and effective method for the detection of CN–. Here, a self-assembly strategy based on pillar[5]arene P5 and azine derivative AZ was used to construct supramolecular sensors, and it was found that the detection effect of CN– was significantly improved by the assembly strategy. The sensitivity of the assembled sensor P5-AZ to CN– is more than 10 times higher than that of AZ. The detect mechanism was further investigated by theoretical calculations and 1H NMR. The results showed that AZ detects CN– by a deprotonation process with fluorescence enhancement, while P5-AZ improves the sensitivity of CN– recognition through hydrogen bonding, anion-π and anion-dipole interactions, as well as the strong bonding ability of the assembly. Supramolecular assembly P5-AZ has the advantages of low toxicity, high sensitivity, and more importantly, it provides a method to detect CN– sensitivity in the aqueous phase and organisms by host-guest assembly.

DOI: 10.1002/cjoc.202400394

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400394