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从临床和遗传学角度揭示治疗精神分裂症的前景看好的神经影像生物标记物
作者:小柯机器人 发布时间:2024/5/7 16:16:47

西安交通大学Tie-Lin Yang等研究人员合作总结,从临床和遗传学角度揭示治疗精神分裂症的前景看好的神经影像生物标记物。2024年5月4日,《神经科学通报》杂志在线发表了这项成果。

研究人员旨在讨论利用临床多模态神经成像和成像遗传学,识别精神分裂症潜在生物标记物的当前和前瞻性方法。研究人员首先通过表型分类和神经影像基因组学描述了成像衍生表型(IDP)。其次,研究人员通过观察性研究和随机对照试验中的临床证据讨论了多模态神经成像的应用。第三,考虑到IDP的遗传证据,研究人员讨论了如何利用神经影像数据作为中间表型,通过多基因风险评分和孟德尔随机化进行关联推断。最后,研究人员讨论了机器学习作为验证生物标记物的最佳方法。
 
总之,未来以神经影像生物标志物为重点的研究工作旨在增进人们对精神分裂症的了解。

据了解,精神分裂症是一种复杂而严重的脑部疾病。神经科学家对使用基于磁共振的脑IDP来研究精神疾病的病因越来越感兴趣。IDP在识别大脑异常方面具有宝贵的临床优势和生物学意义。

附:英文原文

Title: Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives

Author: Guo, Jing, He, Changyi, Song, Huimiao, Gao, Huiwu, Yao, Shi, Dong, Shan-Shan, Yang, Tie-Lin

Issue&Volume: 2024-05-04

Abstract: Schizophrenia is a complex and serious brain disorder. Neuroscientists have become increasingly interested in using magnetic resonance-based brain imaging-derived phenotypes (IDPs) to investigate the etiology of psychiatric disorders. IDPs capture valuable clinical advantages and hold biological significance in identifying brain abnormalities. In this review, we aim to discuss current and prospective approaches to identify potential biomarkers for schizophrenia using clinical multimodal neuroimaging and imaging genetics. We first described IDPs through their phenotypic classification and neuroimaging genomics. Secondly, we discussed the applications of multimodal neuroimaging by clinical evidence in observational studies and randomized controlled trials. Thirdly, considering the genetic evidence of IDPs, we discussed how can utilize neuroimaging data as an intermediate phenotype to make association inferences by polygenic risk scores and Mendelian randomization. Finally, we discussed machine learning as an optimum approach for validating biomarkers. Together, future research efforts focused on neuroimaging biomarkers aim to enhance our understanding of schizophrenia.

DOI: 10.1007/s12264-024-01214-1

Source: https://link.springer.com/article/10.1007/s12264-024-01214-1

期刊信息

Neuroscience Bulletin《神经科学通报》,创刊于2006年。隶属于施普林格·自然出版集团,最新IF:5.6

官方网址:https://link.springer.com/journal/12264
投稿链接:https://mc03.manuscriptcentral.com/nsb