近日，美国南加州大学Yang Chai及其课题组发现，血管结构通过P53-PDGF信号调节小鼠门齿间充质基质细胞的异质性。相关论文于2024年5月3日在线发表在《细胞—干细胞》杂志上。

研究人员表示，MSC驻留在微环境中，以维持组织稳态并促进修复和再生。虽然血液和淋巴管的生理功能已被深入研究，但它们对作为微环境成分的间充质干细胞的调控作用在很大程度上仍不为人所知。

附：英文原文

Title: Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor

Author: Tingwei Guo, Fei Pei, Mingyi Zhang, Takahiko Yamada, Jifan Feng, Junjun Jing, Thach-Vu Ho, Yang Chai

Issue&Volume: 2024-05-03

Abstract: Mesenchymal stem cells (MSCs) reside in niches to maintain tissue homeostasis and contribute to repair and regeneration. Although the physiological functions of blood and lymphatic vasculature are well studied, their regulation of MSCs as niche components remains largely unknown. Using adult mouse incisors as a model, we uncover the role of Trp53 in regulating vascular composition through THBS2 to maintain mesenchymal tissue homeostasis. Loss of Trp53 in GLI1+ progeny increases arteries and decreases other vessel types. Platelet-derived growth factors from arteries deposit in the MSC region and interact with PDGFRA and PDGFRB. Significantly, PDGFRA+ and PDGFRB+ cells differentially contribute to defined cell lineages in the adult mouse incisor. Collectively, our results highlight Trp53’s importance in regulating the vascular niche for MSCs. They also shed light on how different arterial cells provide unique cues to regulate MSC subpopulations and maintain their heterogeneity. Furthermore, they provide mechanistic insight into MSC-vasculature crosstalk.

DOI: 10.1016/j.stem.2024.04.011

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00138-3