暨南大学Li Zhang等研究人员合作发现，跑步机运动重塑皮层星形胶质细胞和神经元活动来改善慢性酒精暴露下的运动学习缺陷。2024年5月28日，国际知名学术期刊《神经科学通报》在线发表了这一成果。

研究人员揭示了运动训练在大脑皮层神经元和星形胶质细胞功能恢复中的作用。通过使用慢性酒精注射小鼠模型，研究人员发现星形胶质细胞过度活跃，同时初级运动皮层树突棘缺失和神经元活性降低。

另一方面，持续的跑步机运动训练改善了神经棘的形成，抑制了反应性星形胶质细胞，缓解了酒精暴露引起的运动学习障碍。这些数据共同支持了耐力运动在酗酒后运动功能康复中的作用。

据了解，酗酒可能通过影响神经元和星形胶质细胞的活动，诱发包括运动学习障碍在内的各种神经系统疾病。体育锻炼是补救突触损失和运动障碍的一种有效方法，这一点已在之前的研究中得到证实。

附：英文原文

Title: Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure

Author: Liu, Linglin, Luo, Lanzhi, Wei, Ji-an, Xu, Xintong, So, Kwok-Fai, Zhang, Li

Issue&Volume: 2024-05-28

Abstract: Alcohol abuse induces various neurological disorders including motor learning deficits, possibly by affecting neuronal and astrocytic activity. Physical exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous works. In this study, we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic functions. Using a chronic alcohol injection mouse model, we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor cortex. Persistent treadmill exercise training, on the other hand, improved neural spine formation and inhibited reactive astrocytes, alleviating motor learning deficits induced by alcohol exposure. These data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.

DOI: 10.1007/s12264-024-01226-x

Source: https://link.springer.com/article/10.1007/s12264-024-01226-x