德国海德堡大学医院Faith H.A. Osier团队近期取得重要工作进展，他们研究提出Fc介导的效应功能的广度与人类接受疟疾挑战后的临床免疫力有关。相关研究成果2024年5月23日在线发表于《免疫学》杂志上。

据介绍，疟疾是一种威胁生命的疾病，对全球健康具有重要意义，特别是在撒哈拉以南非洲。生长抑制试验（GIA）通常用于评估、优先考虑和量化疟疾血期候选疫苗的疗效，但不能可靠地预测自然获得或疫苗诱导的保护作用。在半免疫志愿者中进行的受控人类疟疾挑战研究提供了一个难得的机会，可以有力地确定保护的机制相关性。

研究人员利用这个平台对七种与恶性疟原虫红细胞裂殖子期免疫相关的功能性抗体测定进行了正面比较。Fc介导的效应功能与预防疟疾临床症状和寄生虫指数型增殖密切相关，而金标准GIA则没有。Fc介导的效应物功能的广度区分了挑战后的临床免疫。

总之，这一研究改变了人们对疟疾免疫机制的理解，并对疫苗开发具有重要意义。

附：英文原文

Title: Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge

Author: Irene N. Nkumama, Rodney Ogwang, Dennis Odera, Fauzia Musasia, Kennedy Mwai, Lydia Nyamako, Linda Murungi, James Tuju, Kristin Fürle, Micha Rosenkranz, Rinter Kimathi, Patricia Njuguna, Mainga Hamaluba, Melissa C. Kapulu, Roland Frank, Faith H.A. Osier

Issue&Volume: 2024-05-23

Abstract: Malaria is a life-threatening disease of global health importance, particularly in sub-Saharan Africa. The growth inhibition assay (GIA) is routinely used to evaluate, prioritize, and quantify the efficacy of malaria blood-stage vaccine candidates but does not reliably predict either naturally acquired or vaccine-induced protection. Controlled human malaria challenge studies in semi-immune volunteers provide an unparalleled opportunity to robustly identify mechanistic correlates of protection. We leveraged this platform to undertake a head-to-head comparison of seven functional antibody assays that are relevant to immunity against the erythrocytic merozoite stage of Plasmodium falciparum. Fc-mediated effector functions were strongly associated with protection from clinical symptoms of malaria and exponential parasite multiplication, while the gold standard GIA was not. The breadth of Fc-mediated effector function discriminated clinical immunity following the challenge. These findings present a shift in the understanding of the mechanisms that underpin immunity to malaria and have important implications for vaccine development.

DOI: 10.1016/j.immuni.2024.05.001

Source: https://www.cell.com/immunity/fulltext/S1074-7613(24)00233-4