近日，德国欧洲生物学实验室Gautam Dey等研究人员合作发现，。这一研究成果发表在2024年5月22日出版的国际学术期刊《自然》上。

研究人员采用比较基因组学和超微结构成像的综合方法，研究了动物和真菌的近亲Ichthyosporea的有丝分裂策略。研究人员发现，该支系中的物种分化为真菌样的封闭式有丝分裂或动物样的开放式有丝分裂，可能是为了支持不同的多核或无核状态。这些研究结果表明，多核生命周期有利于封闭有丝分裂的演化。

据介绍，真核生物在细胞分裂过程中重塑核包膜的策略有两个极端：在开放式有丝分裂中分解核膜或在封闭式有丝分裂中构建核内纺锤体。这两类有丝分裂重塑都涉及核心分裂机制的关键差异，但采用特定机制的演化原因尚不清楚。

附：英文原文

Title: Life-cycle-coupled evolution of mitosis in close relatives of animals

Author: Shah, Hiral, Olivetta, Marine, Bhickta, Chandni, Ronchi, Paolo, Trupini, Monika, Tromer, Eelco C., Toli, Iva M., Schwab, Yannick, Dudin, Omaya, Dey, Gautam

Issue&Volume: 2024-05-22

Abstract: Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis1,2. Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural imaging approach to investigate mitotic strategies in Ichthyosporea, close relatives of animals and fungi. We show that species in this clade have diverged towards either a fungal-like closed mitosis or an animal-like open mitosis, probably to support distinct multinucleated or uninucleated states. Our results indicate that multinucleated life cycles favour the evolution of closed mitosis.

DOI: 10.1038/s41586-024-07430-z

Source: https://www.nature.com/articles/s41586-024-07430-z