美国麻省理工学院Xuanhe Zhao等研究人员合作开发出不同器官上的黏附性抗纤维化界面。相关论文于2024年5月22日在线发表于国际学术期刊《自然》。

研究人员证明，与无粘性的植入物-组织界面相比，粘性植入物-组织界面可降低炎症细胞渗入粘性植入物-组织界面的水平，从而减轻纤维囊在不同动物模型（包括大鼠、小鼠、人源化小鼠和猪）中的形成。组织学分析表明，在体内使用12周后，粘性植入物-组织界面不会在腹壁、结肠、胃、肺和心脏等不同器官上形成可观察到的纤维囊。

为了验证这一假设，研究人员还进行了体外蛋白质吸附、多重Luminex检测、定量PCR、免疫荧光分析和RNA测序。研究人员还在大鼠模型中进一步展示了，带有粘合界面的植入式电极在12周内实现的长期双向电气通信。这些发现为长期抗纤维化植入物-组织界面提供了一种有前景的策略。

据悉，由于异物反应以及随后在植入物-组织界面形成的纤维囊，植入的生物材料和设备的功能和疗效长期受到影响。

附：英文原文

Title: Adhesive anti-fibrotic interfaces on diverse organs

Author: Wu, Jingjing, Deng, Jue, Theocharidis, Georgios, Sarrafian, Tiffany L., Griffiths, Leigh G., Bronson, Roderick T., Veves, Aristidis, Chen, Jianzhu, Yuk, Hyunwoo, Zhao, Xuanhe

Issue&Volume: 2024-05-22

Abstract: Implanted biomaterials and devices face compromised functionality and efficacy in the long term owing to foreign body reactions and subsequent formation of fibrous capsules at the implant–tissue interfaces1,2,3,4. Here we demonstrate that an adhesive implant–tissue interface can mitigate fibrous capsule formation in diverse animal models, including rats, mice, humanized mice and pigs, by reducing the level of infiltration of inflammatory cells into the adhesive implant–tissue interface compared to the non-adhesive implant–tissue interface. Histological analysis shows that the adhesive implant–tissue interface does not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung and heart, over 12 weeks in vivo. In vitro protein adsorption, multiplex Luminex assays, quantitative PCR, immunofluorescence analysis and RNA sequencing are additionally carried out to validate the hypothesis. We further demonstrate long-term bidirectional electrical communication enabled by implantable electrodes with an adhesive interface over 12 weeks in a rat model in vivo. These findings may offer a promising strategy for long-term anti-fibrotic implant–tissue interfaces.

DOI: 10.1038/s41586-024-07426-9

Source: https://www.nature.com/articles/s41586-024-07426-9