荷兰莱顿大学Sjoerd H. van der Burg研究小组发现，免疫疗法激活的T细胞可招募活化的M1样巨噬细胞。该项研究成果于2024年5月16日在线发表在《癌细胞》杂志上。

据介绍，通过免疫疗法彻底清除肿瘤与完全协调的先天性和适应性免疫反应有关，但人们对每种免疫细胞亚群的确切贡献了解有限。

附：英文原文

Title: Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

Author: Marit J. van Elsas, Jim Middelburg, Camilla Labrie, Jessica Roelands, Gaby Schaap, Marjolein Sluijter, Ruxandra Tonea, Vitalijs Ovcinnikovs, Katy Lloyd, Janine Schuurman, Samantha J. Riesenfeld, Thomas F. Gajewski, Noel F.C.C. de Miranda, Thorbald van Hall, Sjoerd H. van der Burg

Issue&Volume: 2024-05-16

Abstract: Total tumor clearance through immunotherapy is associated with a fully coordinated innate and adaptive immune response, but knowledge on the exact contribution of each immune cell subset is limited. We show that therapy-induced intratumoral CD8+ T cells recruited and skewed late-stage activated M1-like macrophages, which were critical for effective tumor control in two different murine models of cancer immunotherapy. The activated CD8+ T cells summon these macrophages into the tumor and their close vicinity via CCR5 signaling. Exposure of non-polarized macrophages to activated T cell supernatant and tumor lysate recapitulates the late-stage activated and tumoricidal phenotype in vitro. The transcriptomic signature of these macrophages is also detected in a similar macrophage population present in human tumors and coincides with clinical response to immune checkpoint inhibitors. The requirement of a functional co-operation between CD8+ T cells and effector macrophages for effective immunotherapy gives warning to combinations with broad macrophage-targeting strategies.

DOI: 10.1016/j.ccell.2024.04.011

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00135-1