荷兰癌症研究所Emile Voest团队完成了转移性癌症中微生物组的泛癌症分析。这一研究成果于2024年4月9日在线发表在国际学术期刊《细胞》上。

为了研究转移瘤中微生物群落的存在及其相关性，研究人员整合了4160例转移瘤活检样本中基于图谱和组装的元基因组学、基因组学、转录组学和临床数据。研究人员发现了微生物的器官特异性向性、缺氧肿瘤中厌氧菌的富集、微生物多样性与肿瘤浸润中性粒细胞之间的关联，以及梭杆菌属与肺癌免疫检查点阻断（ICB）耐受性之间的关联。

此外，纵向肿瘤取样揭示了微生物群落的时间演化，并确定了ICB后耗竭的细菌。研究人员建立了转移性肿瘤微生物组的泛癌症资源，这可能有助于推进治疗策略。

研究人员表示，微生物群落常驻于人体的多个微环境，是宿主免疫系统和抗癌疗法反应的重要调节剂。最近的研究表明，原发性肿瘤内存在复杂的微生物群落。

附：英文原文

Title: A pan-cancer analysis of the microbiome in metastatic cancer

Author: Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Michal No, Ingrid Hofland, Joris L. Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L. Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest

Issue&Volume: 2024-04-09

Abstract: Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present within primary tumors. To investigate the presence and relevance of the microbiome in metastases, we integrated mapping and assembly-based metagenomics, genomics, transcriptomics, and clinical data of 4,160 metastatic tumor biopsies. We identified organ-specific tropisms of microbes, enrichments of anaerobic bacteria in hypoxic tumors, associations between microbial diversity and tumor-infiltrating neutrophils, and the association of Fusobacterium with resistance to immune checkpoint blockade (ICB) in lung cancer. Furthermore, longitudinal tumor sampling revealed temporal evolution of the microbial communities and identified bacteria depleted upon ICB. Together, we generated a pan-cancer resource of the metastatic tumor microbiome that may contribute to advancing treatment strategies.

DOI: 10.1016/j.cell.2024.03.021

Source: https://www.cell.com/cell/fulltext/S0092-8674(24)00312-X