青岛科技大学王庆富光团队报道了光响应自裂解L-谷氨酸基聚酯纳米粒子的三组分聚合控制药物释放。相关研究成果于2024年3月4日发表在《中国高分子科学杂志》。

L-谷氨酸（LA）是一种生物基、无毒、环保的生物质材料。

该研究报道了Passerini三组分聚合（P-3CP）在温和条件下直接制备LA基光响应聚酯（PLTDs）的应用。获得了摩尔质量高达8500 g/mol并且高产率超过90%的PLTDs。采用紫外-可见光谱（UV-Vis）、体积排除色谱（SEC）、核磁共振（NMR）和液相色谱-质谱（LC-MS），对PLTDs的化学结构和光响应自裂解行为进行了全面表征。

同时，通过纳米沉淀法配制了单分散PLTD基阿霉素负载纳米颗粒（PLTD-DOX-NP）（尺寸=193nm，PDI=0.018）。在光诱导解聚后，PLTD-DOX-NP快速分解，导致在13秒内80%的药物突然释放。此外，根据生物毒性测试，PLTD-NP在辐照前后都具有足够的生物安全性。总体而言，P-3CP与生物可再生LA基单体的结合符合绿色化学的原则，显著简化了光响应聚合物的合成途径。

附：原文原文

Title: Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

Author: Xiao-Fei Sun, Xu Zhang, Shu-Ping Song, Ya-Qun Yao, Yan Zhang, Cheng-Liang Wang, Jing-Jiang Sun, Qing-Fu Wang

Issue&Volume: 2024-03-04

Abstract: L-glutamic acid (LA) is a bio-based, non-toxic, environmentally friendly material derived from biomass. The present study reports the application of Passerini three-component polymerization (P-3CP) for the straightforward preparation of LA-based light-responsive polyesters (PLTDs) under mild conditions. PLTDs with molar masses up to 8500 g/mol and high yields exceeding 90% are obtained. The chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible (UV-Vis) spectroscopy, size exclusion chromatography (SEC), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography mass spectrometry (LC-MS). Meanwhile, monodisperse PLTD-based doxorubicin-loaded nanoparticles (PLTD-DOX-NP) (size=193 nm, PDI=0.018) are formulated by nanoprecipitation method. Upon light-induced depolymerization, the PLTD-DOX-NP undergoes rapid decomposition, resulting in a burst release of 80% cargo within 13 s. Furthermore, according to biological toxicity tests, the PLTD-NP possesses adequate biosafety, both before and after irradiation. Overall, the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry, significantly simplifying the synthetic pathway of light-responsive polymers.

DOI: 10.1007/s10118-024-3093-9

Source: https://www.cjps.org/en/article/doi/10.1007/s10118-024-3093-9/