上海交通大学医学院Yangtai Guan和美国石溪大学Yu Cai共同合作，近期取得重要工作进展。他们研究提出了神经免疫疾病中细胞外囊泡与自噬的相互作用的观点。相关研究成果2024年2月29日在线发表于《神经科学通报》杂志上。

据介绍，神经免疫疾病，如多发性硬化症、视神经脊髓炎谱系障碍、重症肌无力和格林-巴利综合征，其特征是免疫系统和神经系统功能障碍。越来越多的证据表明，细胞外囊泡和自噬与这些疾病的发病机制密切相关。

研究人员总结了目前对神经免疫疾病中细胞外囊泡和自噬之间相互作用的理解，并讨论了其潜在的诊断和治疗应用。

此外，研究人员强调需要进一步探讨，以充分了解这些疾病的潜在机制，并制定新的诊断和治疗策略。

附：英文原文

Title: Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders

Author: Ai, Xiwen, Yu, Haojun, Cai, Yu, Guan, Yangtai

Issue&Volume: 2024-02-29

Abstract: Neuroimmune disorders, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis, and Guillain–Barré syndrome, are characterized by the dysfunction of both the immune system and the nervous system. Increasing evidence suggests that extracellular vesicles and autophagy are closely associated with the pathogenesis of these disorders. In this review, we summarize the current understanding of the interactions between extracellular vesicles and autophagy in neuroimmune disorders and discuss their potential diagnostic and therapeutic applications. Here we highlight the need for further research to fully understand the mechanisms underlying these disorders, and to develop new diagnostic and therapeutic strategies.

DOI: 10.1007/s12264-024-01183-5

Source: https://link.springer.com/article/10.1007/s12264-024-01183-5