北京大学王欢团队报道了化学反应系统中增强扩散问题的测量比较。相关研究成果于2024年3月19日发表在《中国化学》。

从化学到生物物理再到材料科学，化学反应中的分子扩散问题引起了人们越来越多的兴趣。化学反应涉及键的断裂和形成，其时间尺度通常在fs到ps的数量级，而分子扩散发生在μs到ms的时间尺度。考虑到截然不同的尺度，这两个过程通常被认为是正交的。

一系列结果表明，酶的扩散以底物依赖的方式增强，并进一步扩展到小分子反应系统，挑战了这一经典范式。然而，使用不同技术的不同小组的结果在数量上并不一致，总体机制尚待了解。

研究人员总结了关于扩散问题的实验研究，并试图将解释与理解测量工具的极限和反应系统的化学性质相协调。了解化学反应中的分子扩散将为设计化学系统提供新的思路，例如以可控的方式在纳米尺度上收获功的分子机器。

附：英文原文

Title: Comparison of Measurements for Enhanced Diffusion Problem in Chemical Reaction Systems

Author: Ah-Young Jee, Ziyang Wen, Huan Wang

Issue&Volume: 2024-03-19

Abstract: The problem of molecular diffusion in the soup of chemical reactions attracts mounting interest across fields ranging from chemistry to biophysics to material science. Chemical reactions involve bond breakup and formation, whose time scale is typically on the orders of fs to ps, while molecular diffusion occurs at time scales of μs to ms. The two processes are often considered orthogonal, given the vastly different scales. The serial results show that the enzyme's diffusion is enhanced in a substrate-dependent manner, which was further extended to small molecule reaction systems, challenging this classical paradigm. However, the results from different groups using different techniques do not quantitatively agree, and a general mechanism is yet to be understood. We summarize experimental studies on diffusion problems and seek to reconcile the interpretation with understanding the limits of measurement tools and the chemical nature of reaction systems. Understanding molecular diffusion in chemical reactions will provide fresh thoughts in designing chemical systems such as molecular machines that harvest work at the nanoscale in a controllable manner.

DOI: 10.1002/cjoc.202300791

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202300791