西北工业大学Peng Li和Yunxiu Zhang共同合作，近期取得重要工作进展。他们通过利用仿生细胞膜包裹肿瘤组织从而阻断代谢产物转运。相关研究成果2024年2月1日在线发表于《科学通报》杂志上。

据介绍，抑制肿瘤细胞的代谢物转运有望达到抗肿瘤的效果。

研究人员提出了一种创新策略，用强烈粘附在肿瘤细胞细胞膜上的多酚聚合物，阻碍代谢物通过原位围攻肿瘤细胞的递送。同时，这些聚合物在肿瘤氧化应激微环境的诱导下进行自交联，在肿瘤细胞表面形成粘附涂层。这种多酚涂层有效地阻碍了葡萄糖的吸收，减少了乳酸、谷胱甘肽和三磷酸腺苷等代谢产物，同时也导致活性氧在肿瘤细胞中积累。对包括2D细胞、3D多细胞肿瘤球体和异种移植物肿瘤在内的各种肿瘤模型的研究表明，多酚聚合物通过阻断关键代谢产物转运过程，有效抑制肿瘤细胞的生长。

此外，这种高度粘附的涂层可以结合肿瘤细胞，抑制其转移和侵袭。

总之，这项工作确定了多酚聚合物是一种有前景的抗癌候选物，其机制是阻碍肿瘤细胞的物质运输。

附：英文原文

Title: Bioinspired cytomembrane coating besieges tumor for blocking metabolite transportation

Author: anonymous

Issue&Volume: 2024/02/01

Abstract: The metabolite transport inhibition of tumor cells holds promise to achieve anti-tumor efficacy. Herein, we presented an innovative strategy to hinder the delivery of metabolites through the in-situ besieging tumor cells with polyphenolic polymers that strongly adhere to the cytomembrane of tumor cells. Simultaneously, these polymers underwent self-crosslinking under the induction of tumor oxidative stress microenvironment to form an adhesive coating on the surface of the tumor cells. This polyphenol coating effectively obstructed glucose uptake, reducing metabolic products such as lactic acid, glutathione, and adenosine triphosphate, while also causing reactive oxygen species to accumulate in the tumor cells. The investigation of various tumor models, including 2D cells, 3D multicellular tumor spheroids, and xenograft tumors, demonstrated that the polyphenolic polymers effectively inhibited the growth of tumor cells by blocking key metabolite transport processes. Moreover, this highly adhesive coating could bind tumor cells to suppress their metastasis and invasion. This work identified polyphenolic polymers as a promising anticancer candidate with a mechanism by impeding the mass transport of tumor cells.

DOI: 10.1016/j.scib.2024.01.040

Source: https://www.sciencedirect.com/science/article/abs/pii/S2095927324000677