北京交通大学胡远渡团队报道了液滴微流体结合外交联法制备球形磁性海藻酸铁微凝胶，及其pH依赖性Fe³⁺释放行为研究。相关研究成果发表在2024年12月6日出版的《中国高分子科学杂志》。

由于海藻酸铁（III） (Fe-Alg)微凝胶在生物医学和环境工程中的快速发展和潜在应用，该研究探索了使用液滴微流体结合外部离子交联方法，制备球形海藻酸铁微凝胶并对其进行表征。

该研究主要关注Fe³⁺的作用，并考察了其在不同离子条件和还原或氧化状态下，对微凝胶物理/化学性质的影响。Fe³⁺在这些微凝胶中的pH依赖性释放行为，表明了它们潜在的生物医学和环境应用。此外，通过原位氧化，微凝胶可以简单地表现出磁性，这可以进一步用于靶向药物递送和磁分离技术。

附：英文原文

Title: Spherical Magnetic Fe-Alginate Microgels Fabricated by Droplet-Microfluidics Combining with an External Crosslinking Approach and the Study of Their pH Dependent Fe³⁺ Release Behaviors

Author: Jie Chen, Run-Yu Yu, Kai-Qi Wang, Zhe-Yu Zhang, Arezoo Ardekani, Yuan-Du Hu

Issue&Volume: 2024-12-06

Abstract: Due to the rapid development and potential applications of iron(III)-alginate (Fe-Alg) microgels in biomedical as well as environmental engineering, this study explores the preparation and characterization of spherical Fe-Alg microgels using droplet microfluidics combined with an external ionic crosslinking method. This study focused on the role of Fe3+ and examined its effects on the physical/chemical properties of microgels under different ionic conditions and reduced or oxidized states. The pH-dependent release behavior of Fe3+ from these microgels demonstrates their potential biomedical and environmental applications. Furthermore, the microgels can exhibit magnetism simply by utilizing in situ oxidation, which can be further used for targeted drug delivery and magnetic separation technologies.

DOI: 10.1007/s10118-025-3257-2

Source: https://www.cjps.org/en/article/doi/10.1007/s10118-025-3257-2/