中国科学技术大学丁勇等研究人员合作发现，OsbZIP27协调OsHUB1和OsHUB2来调节水稻抗旱性。该研究于2024年12月4日在线发表于《遗传学报》。

研究人员发现OsbZIP27直接与OsHUB1/2相互作用，通过结合OsHAK1和OsGLN1的启动子调控水稻的抗旱性，进而实现H2B泛素化（H2Bub）和转录激活。

与此一致，OsbZIP27的突变降低了OsHAK1和OsGLN1的转录，导致水稻对干旱胁迫的敏感性增加。此外，OsHUB1和OsHUB2功能缺失会导致对干旱胁迫的过敏，而OsHUB2过表达则增强了抗旱性。

综合来看，这些研究结果表明，OsbZIP27与OsHUB1/2协调，通过增加H2Bub和OsHAK1、OsGLN1的表达，增强水稻的抗旱性。

据了解，组蛋白H2Bub与转录激活正相关，但受H2Bub影响的基因程序增强耐旱性在很大程度上仍然未知。

附：英文原文

Title: OsbZIP27 coordinates with OsHUB1 and OsHUB2 to modulate drought tolerance in rice

Author: Wenge W u a b e, Yong Ding c d

Issue&Volume: 2024/12/04

Abstract: Histone H2B ubiquitination (H2Bub) is positively linked to transcriptional activation, but the genetic programs affected by H2Bub to enhance drought tolerance remain largely unknown. Here, we show that OsbZIP27 interacts directly with OsHUB1/2 to regulate drought tolerance in rice by binding to the promoters of OsHAK1 and OsGLN1 to achieve H2Bub and transcriptional activation. Consistently, mutations in OsbZIP27 reduce transcription of OsHAK1 and OsGLN1, resulting in increased sensitivity to drought stress. Moreover, loss of OsHUB1 and OsHUB2 function causes hypersensitivity to drought stress, whereas OsHUB2 overexpression enhances drought tolerance. Together, our results indicate that OsbZIP27 coordinates with OsHUB1/2 to enhance rice drought tolerance by increasing H2Bub and expression of OsHAK1 and OsGLN1.

DOI: 10.1016/j.jgg.2024.11.016

Source: https://www.sciencedirect.com/science/article/abs/pii/S167385272400331X