浙江大学赵鹏举等研究人员合作报道来自514只湖羊基因组的种群历史、结构变异景观和复杂性状的基因组见解。相关论文于2024年12月4日在线发表于国际学术期刊《遗传学报》。

研究人员分析了来自蒙古羊品种代表的697只羊基因组。研究表明，湖羊的祖先大约在3000年前从蒙古群体中分离出来。随着湖羊从北方迁徙并在约1000年前在太湖平原繁荣发展，它们形成了独特的遗传基础和表型特征，这些特征在基因组的选择扫荡和结构变异景观中得到了体现。

与繁殖性状（BMPR1B和TDRD10）和角表型（RXFP2）相关的基因，在湖羊基因组中表现出显著的选择扫荡。全基因组关联分析揭示，LOC101110773、MAST2和ZNF385B的结构变异可能分别显著影响湖羊的去角性、乳头数和早期生长。

该研究为湖羊的演化历史提供了洞察，并可能成为增强对湖羊复杂性状理解的宝贵遗传资源。

据了解，湖羊是中国太湖平原的本土品种，以其高繁殖力著称。尽管胡羊属于蒙古羊群体，但其种群历史和遗传结构仍不明确。

附：英文原文

Title: Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes

Author: Zhengguang Wang a b, Pengju Zhao a b

Issue&Volume: 2024/12/04

Abstract: Hu sheep is an indigenous breed from the Taihu Lake Plain in China, known for its high fertility. Although Hu sheep belong to the Mongolian group, their demographic history and genetic architecture remain inconclusive. Here, we analyze 697 sheep genomes from representatives of Mongolian sheep breeds. Our study suggests that the ancestral Hu sheep first separated from the Mongolian group approximately 3000 years ago. As Hu sheep migrated from the north and flourished in the Taihu Lake Plain around 1000 years ago, they developed a unique genetic foundation and phenotypic characteristics which are evident in the genomic footprints of selective sweeps and structural variation landscape. Genes associated with reproductive traits (BMPR1B and TDRD10) and horn phenotype (RXFP2) exhibit notable selective sweeps in the genome of Hu sheep. A genome-wide association analysis reveals that structural variations at LOC101110773, MAST2, and ZNF385B may significantly impact polledness, teat number, and early growth in Hu sheep, respectively. Our study offers insights into the evolutionary history of Hu sheep and may serve as a valuable genetic resource to enhance the understanding of complex traits in Hu sheep.

DOI: 10.1016/j.jgg.2024.11.015

Source: https://www.sciencedirect.com/science/article/abs/pii/S1673852724003308