杭州师范大学王永杰等研究人员合作总结了YAP信号通路在胶质细胞中的作用。相关论文于2024年11月6日在线发表在《神经科学通报》杂志上。

研究人员表示，Yes相关蛋白（YAP）是Hippo通路的关键转录共因子及下游效应分子，已成为神经和胶质细胞的主要调控因子之一。

YAP已在多种胶质细胞类型中被发现，包括外周神经系统中的施旺细胞和嗅鞘细胞，以及中枢神经系统中的放射胶质细胞、室管膜细胞、贝尔曼胶质细胞、视网膜穆勒细胞、星形胶质细胞、少突胶质细胞和小胶质细胞。

随着神经科学的发展，理解YAP在胶质细胞生理或病理过程中的功能正在逐步深入。

研究人员旨在从一个整合的视角，总结YAP在胶质细胞及与胶质细胞相关的，神经疾病中的作用及其潜在机制。

附：英文原文

Title: YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases

Author: Lin, Lin, Yuan, Yinfeng, Huang, Zhihui, Wang, Yongjie

Issue&Volume: 2024-11-06

Abstract: Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.

DOI: 10.1007/s12264-024-01308-w

Source: https://link.springer.com/article/10.1007/s12264-024-01308-w