荷兰格罗宁根大学Bart J. L. Eggen团队揭示了多发性硬化中白质损伤进展的空间分辨基因特征。相关论文于2024年11月5日在线发表在《自然—神经科学》杂志上。

为了理解多发性硬化（MS）病灶的发生和进展，研究人员生成了白质（WM）和灰质（GM）MS病灶的空间基因表达图谱。在不同类型的MS病灶中，研究人员发现了由独特基因特征表征的区域，包括在活动性白质病灶周围可识别的边缘。

星形胶质细胞特异性、少突胶质细胞特异性和小胶质细胞特异性基因集的表达变化，特征性地出现在活动性病灶的边缘。此外，研究人员识别了三种白质病灶进展轨迹，预测了正常外观的白质如何发展为活动性白质病灶或混合型活动–非活动病灶。这些数据为MS病灶的动态进展提供了新的见解。

据了解，MS是一种中枢神经系统的炎症性疾病，其特征为髓鞘丧失和进行性神经退行性变。

附：英文原文

Title: Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

Author: Alsema, Astrid M., Wijering, Marion H. C., Miedema, Anneke, Kotah, Janssen M., Koster, Mirjam, Rijnsburger, Merel, van Weering, Hilmar R. J., de Vries, Helga E., Baron, Wia, Kooistra, Susanne M., Eggen, Bart J. L.

Issue&Volume: 2024-11-05

Abstract: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and progressive neurodegeneration. To understand MS lesion initiation and progression, we generate spatial gene expression maps of white matter (WM) and grey matter (GM) MS lesions. In different MS lesion types, we detect domains characterized by a distinct gene signature, including an identifiable rim around active WM lesions. Expression changes in astrocyte-specific, oligodendrocyte-specific and microglia-specific gene sets characterize the active lesion rims. Furthermore, we identify three WM lesion progression trajectories, predicting how normal-appearing WM can develop into WM active or mixed active–inactive lesions. Our data shed light on the dynamic progression of MS lesions.

DOI: 10.1038/s41593-024-01765-6

Source: https://www.nature.com/articles/s41593-024-01765-6