美国南加州大学Tadeja Gracner团队近期取得重要工作进展，他们研究提出，在受孕后最初1000天内接触糖定量配给可预防慢性疾病。相关研究成果
研究人员利用1953年9月英国糖配给结束后的准实验变化，研究了受孕后1000天内糖暴露对糖尿病和高血压的影响。定量配给将糖的摄入量限制在当前饮食指南的范围内，但定量配给后的摄入量几乎翻了一番。使用英国生物库数据比较配给结束前后怀孕的成年人的事件研究设计，研究人员发现早期生活配给分别将糖尿病和高血压风险降低了约35%和20%，并将疾病发作延迟了4年和2年。保护作用在胎儿时期就很明显，并随着产后限糖而增强，尤其是在六个月后可能开始吃固体食物时。仅胎内糖分配给就降低了约三分之一的风险。
附：英文原文
Title: Exposure to sugar rationing in the first 1000 days of life protected against chronic disease
Author: Tadeja Gracner, Claire Boone, Paul J. Gertler
Issue&Volume: 2024-10-31
Abstract: We examined the impact of sugar exposure within 1000 days since conception on diabetes and hypertension, leveraging quasi-experimental variation from the end of the United Kingdom’s sugar rationing in September 1953. Rationing restricted sugar intake to levels within current dietary guidelines, yet consumption nearly doubled immediately post-rationing. Using an event study design with UK Biobank data comparing adults conceived just before or after rationing ended, we found that early-life rationing reduced diabetes and hypertension risk by about 35% and 20%, respectively, and delayed disease onset by 4 and 2 years. Protection was evident with in-utero exposure and increased with postnatal sugar restriction, especially after six months when solid foods likely began. In-utero sugar rationing alone accounted for about one third of the risk reduction.
DOI: adn5421
Source: https://www.science.org/doi/10.1126/science.adn5421