北京理工大学王博团队报道了提高生物实体稳定性和功能性能的网状化学。相关研究成果于2024年11月19日发表在《美国化学会杂志》。

针对生物实体在储存和应用过程中导致不稳定和性能受损的脆弱性，网状化学，特别是通过金属-有机框架（MOFs）和共价有机框架（COFs），为生物实体的稳定和增强提供了多功能平台。

这些高度多孔的框架有助于高效加载和传质，提供封闭环境和选择性渗透性以实现稳定和保护，并实现精细可调的生物界面相互作用和微环境以实现功能优化，显著拓宽了各种生物实体的应用，包括酶、核酸、细胞等。

该文概述了将生物实体与网状框架整合的策略，突出了这些策略中现有问题的新设计思路。它强调了这些生物实体框架在增强稳定性、增强活性、赋予非本地功能和协同生物实体系统方面的关键作用。最后，该文讨论了这些生物复合材料的设计、表征和实际应用中的挑战和前景，旨在激发高性能生物复合材料在这一有前景的领域的进一步发展。

附：英文原文

Title: Reticular Chemistry for Enhancing Bioentity Stability and Functional Performance

Author: Mengchu Feng, Chunyan Xing, Yehao Jin, Xiao Feng, Yuanyuan Zhang, Bo Wang

Issue&Volume: November 19, 2024

Abstract: Addressing the fragility of bioentities that results in instability and compromised performance during storage and applications, reticular chemistry, specifically through metal–organic frameworks (MOFs) and covalent organic frameworks (COFs), offers versatile platforms for stabilization and enhancement of bioentities. These highly porous frameworks facilitate efficient loading and mass transfer, offer confined environments and selective permeability for stabilization and protection, and enable finely tunable biointerfacial interactions and microenvironments for function optimization, significantly broadening the applications of various bioentities, including enzymes, nucleic acids, cells, etc. This Perspective outlines strategies for integrating bioentities with reticular frameworks, highlighting new design ideas for existing issues within these strategies. It emphasizes the crucial roles of these frameworks for bioentities in enhancing stability, boosting activity, imparting non-native functions, and synergizing bioentity systems. Concluding with a discussion of the challenges and prospects in the design, characterization, and practical applications of these biocomposites, this Perspective aims to inspire further development of high-performance biocomposites in this promising field.

DOI: 10.1021/jacs.4c09259

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.4c09259