北京大学宛新华团队报道了，聚苯乙炔衍生物纳米极聚集物的区域选择性和同手性超分子聚合。相关研究成果发表在2024年11月12日出版的《德国应用化学》。

生物同手性是生命的标志。超分子聚合在自然界中可以有效地实现高层次的同手性，但尚未得到很好的探索。

该文报道了由合成螺旋状聚苯乙炔，或手性和非手性聚苯乙炔的手性扩增共组装制成的，手性纳米极聚集体的区域选择性和均手性超分子聚合。具有高螺旋方向偏好的扭曲纳米极聚集体，作为单体（聚集体）以头尾区域选择性和逐步的方式聚合成超分子链。

对映体聚集体的超分子共聚，有利于形成TEM所示的均手性分级超分子结构。聚集体的手性六方柱状中间相对立体选择性有反应。

该项工作为可控和有效地构建功能性手性超分子材料打开了大门，加深了对分级生物同手性的理解。

附：英文原文

Title: Regioselective and Homochiral Supramolecular Polymerization of Nanotadpole Aggremers of Poly(phenylacetylene) Derivatives

Author: Xinhua Wan, Hua Zeng, Peiyao Yu, Jie Zhang

Issue&Volume: 2024-11-12

Abstract: Biological homochirality is a signature of life. Supramolecular polymerization is effective to achieve high hierarchical homochirality in nature, but has not been well-explored. Herein, we report regioselective and homochiral supramolecular polymerization of chiral nanotadpole aggregates made of either synthetic helical poly(phenylacetylene)s or chirality-amplified co-assembly of chiral and achiral poly(phenylacetylene)s. The twisted nanotadpole aggregates with high screw-sense preference polymerized as monomers (aggremers) into supramolecular chains in a head-to-tail regioselective and stepwise manner. Supramolecular copolymerization of enantiomeric aggremers favored formation of homochiral hierarchical supramolecular structures as visualized by TEM. Chiral hexagonal columnar mesophase of aggremers was responsive for the stereoselectivity. The work opens a gate to controllably and effectively construct functional chiral supramolecular materials and deepens the understanding of hierarchical biological homochirality.

DOI: 10.1002/anie.202417792

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202417792