澳大利亚悉尼大学Brandon R. Munn等研究人员发现，神经活动的多尺度组织统一与脑功能相关的尺度依赖理论。相关论文于2024年10月30日在线发表在《细胞》杂志上。

据了解，在不同分辨率下收集的脑记录支持神经编码的不同特征，从而导致与脑功能相关的尺度依赖理论。

研究人员展示了这些不同的特征源于观察到的重尾多尺度功能组织，该组织存在于从斑马鱼和秀丽隐杆线虫的全脑钙成像记录以及果蝇、小鼠和猕猴的感觉区域中。网络模拟表明，这种保守的层次结构增强了信息处理。最后，研究人员发现尽管在行为过程中，细胞协调发生了显著的跨尺度重构，这种组织仍然得以维持。

这些研究结果表明，这种非线性的神经活动组织是一个普遍原则，因其能够在多个时空尺度上适应性地将行为与神经动态联系起来，同时平衡功能的弹性和信息处理效率。

附：英文原文

Title: Multiscale organization of neuronal activity unifies scale-dependent theories of brain function

Author: Brandon R. Munn, Eli J. Müller, Itia Favre-Bulle, Ethan Scott, Joseph T. Lizier, Michael Breakspear, James M. Shine

Issue&Volume: 2024-10-30

Abstract: Brain recordings collected at different resolutions support distinct signatures of neural coding, leading to scale-dependent theories of brain function. Here, we show that these disparate signatures emerge from a heavy-tailed, multiscale functional organization of neuronal activity observed across calcium-imaging recordings collected from the whole brains of zebrafish and C. elegans as well as from sensory regions in Drosophila, mice, and macaques. Network simulations demonstrate that this conserved hierarchical structure enhances information processing. Finally, we find that this organization is maintained despite significant cross-scale reconfiguration of cellular coordination during behavior. Our findings suggest that this nonlinear organization of neuronal activity is a universal principle conserved for its ability to adaptively link behavior to neural dynamics across multiple spatiotemporal scales while balancing functional resiliency and information processing efficiency.

DOI: 10.1016/j.cell.2024.10.004

Source: https://www.cell.com/cell/abstract/S0092-8674(24)01152-8