青岛大学Ying Wang等研究人员合作探讨癫痫中的白细胞介素。2024年1月24日，《神经科学通报》杂志在线发表了这项成果。

研究人员表示，癫痫是一种无诱因反复发作的慢性神经系统疾病，全球约有6500万人患癫痫。癫痫患者和动物模型的证据表明，神经炎症有助于癫痫的发生和发展。白细胞介素（IL）作为神经炎症的主要促成因素之一，其对癫痫发生和癫痫生成的关联和调节作用受到了深入研究。

IL通常分为促炎细胞因子和抗炎细胞因子，因此被认为在癫痫中具有致病或神经保护作用。然而，有报道称许多IL既有保护作用，也有破坏作用。这可能是由于IL的复杂性，也可能是由于这些IL参与的疾病过程不同。

研究人员总结了不同IL在这些过程中的作用，并概述了最近的研究进展以及针对IL治疗癫痫的临床前和临床研究。

附：英文原文

Title: Interleukins in Epilepsy: Friend or Foe

Author: Dong, Yuan, Zhang, Xia, Wang, Ying

Issue&Volume: 2024-01-24

Abstract: Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures, affecting ~65 million worldwide. Evidence in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of epilepsy. Interleukins (ILs), as one of the major contributors to neuroinflammation, are intensively studied for their association and modulatory effects on ictogenesis and epileptogenesis. ILs are commonly divided into pro- and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in epilepsy. However, both protective and destructive effects have been reported for many ILs. This may be due to the complex nature of ILs, and also possibly due to the different disease courses that those ILs are involved in. In this review, we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances, as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

DOI: 10.1007/s12264-023-01170-2

Source: https://link.springer.com/article/10.1007/s12264-023-01170-2