瑞典乌普萨拉大学Åsa Johansson和Mathias Rask-Andersen共同合作，近期取得重要工作进展。他们研究揭示了肥胖和性别特异性癌症风险。相关研究成果2023年6月12日在线发表于《癌细胞》杂志上。

据介绍，肥胖与几种类型的癌症和脂肪分布有关，性别之间的差异很大，这被认为是一个独立的风险因素。然而，针对性别对癌症风险的影响却鲜有研究。

研究人员评估了脂肪积累和分布对女性和男性癌症风险的影响。研究人员对442519名英国生物库参与者进行了前瞻性研究，研究对象为19种癌症类型和其他组织学亚型，平均随访时间为13.4年。Cox比例风险模型用于评估14种不同肥胖表型对癌症发生率的影响，5%的错误发现率被认为具有统计学意义。除了三种癌症类型外，与脂肪相关的特征与所有癌症相关，与脂肪分布相比，脂肪积累与更多癌症相关。

此外，脂肪的积累或分布对结直肠癌、食管癌和癌症的影响在性别上也存在差异。

附：英文原文

Title: Adiposity and sex-specific cancer risk

Author: Mathias Rask-Andersen, Emma Ivansson, Julia Hglund, Weronica E. Ek, Torgny Karlsson, sa Johansson

Issue&Volume: 2023/06/12

Abstract: Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.

DOI: 10.1016/j.ccell.2023.05.010

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00177-0