法国里昂高等师范学院François Leulier等研究人员合作发现，微生物介导的肠道NOD2刺激改善营养不良胎鼠的线性增长。2023年2月24日出版的《科学》杂志发表了这项成果。

研究人员之前发现一株植物乳杆菌（Lp^WJL）可以缓冲慢性营养不良对无菌幼鼠生长的不利影响。研究人员报道了Lp^WJL抑制了营养不良常规动物的出生后生长，并支持胰岛素样生长因子-1（IGF-1）和胰岛素的产生和活性。研究人员确定了从Lp^WJL分离的细胞壁，以及muramyl二肽和mifamurtide可作为足够的线索来刺激动物生长，尽管营养不足。此外，研究人员发现NOD2在肠上皮细胞中对于Lp^WJL介导的IGF-1的产生和营养不良常规动物的出生后生长促进是必要的。这些发现表明，加上营养，细菌细胞壁或纯化的NOD2配体具有缓解发育迟缓的潜力。

研究人员表示，已知肠道菌群会影响出生后的生长。

附：英文原文

Title: Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

Author: Martin Schwarzer, Umesh Kumar Gautam, Kassem Makki, Anne Lambert, Tomá Brabec, Amélie Joly, Dagmar rtková, Pierre Poinsot, Tereza Novotná, Stéphanie Geoffroy, Pascal Courtin, Petra Petr Hermanová, Renata C. Matos, Jonathan J. M. Landry, Céline Gérard, Anne-Laure Bulteau, Tomá Hudcovic, Hana Kozáková, Dominik Filipp, Marie-Pierre Chapot-Chartier, Marek inkora, Nol Peretti, Ivo Gomperts Boneca, Mathias Chamaillard, Hubert Vidal, Filipe De Vadder, Franois Leulier

Issue&Volume: 2023-02-24

Abstract: The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJL sustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor–1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.

DOI: ade9767

Source: https://www.science.org/doi/10.1126/science.ade9767