美国西奈山伊坎医学院Thomas P. Zwaka等研究人员合作发现，蝙蝠多能干细胞揭示宿主和病毒之间不寻常的瓜葛。2023年2月21日，《细胞》杂志在线发表了这项成果。
研究人员从两种蝙蝠中创造了诱导多能干细胞（iPSC）：野生大马蹄蝠（Rhinolophthem ferrumequinum）和大母耳蝠（Myotis Myotis）。来自两种蝙蝠的诱导多能干细胞表现出相似的特征，其基因表达谱与被病毒攻击的细胞相似。它们也有大量的内源性病毒序列，特别是逆转录病毒。这些结果表明，蝙蝠已经演化出了耐受大量病毒序列的机制，并且可能与病毒之间的关系比以前认为的更紧密。对蝙蝠诱导多能干细胞及其分化后代的进一步研究将有助于深入了解蝙蝠生物学、病毒与宿主之间的关系以及蝙蝠特殊性状的分子基础。
研究人员表示，蝙蝠在哺乳动物中是独特的，因为它们有飞行的能力、喉部回声定位以及耐受病毒。然而，目前还没有可靠的细胞模型来研究蝙蝠生物学或它们对病毒感染的反应。
附：英文原文
Title: Bat pluripotent stem cells reveal unusual entanglement between host and viruses
Author: Marion Déjosez, Arturo Marin, Graham M. Hughes, Ariadna E. Morales, Carlos Godoy-Parejo, Jonathan L. Gray, Yiren Qin, Arun A. Singh, Hui Xu, Javier Juste, Carlos Ibáez, Kris M. White, Romel Rosales, Nancy J. Francoeur, Robert P. Sebra, Dominic Alcock, Thomas L. Volkert, Sébastien J. Puechmaille, Andrzej Pastusiak, Simon D.W. Frost, Michael Hiller, Richard A. Young, Emma C. Teeling, Adolfo García-Sastre, Thomas P. Zwaka
Issue&Volume: 2023-02-21
Abstract: Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However, there are currently no reliable cellular models for studying bat biology or their response to viral infections. Here, we created induced pluripotent stem cells (iPSCs) from two species of bats: the wild greater horseshoe bat (Rhinolophus ferrumequinum) and the greater mouse-eared bat (Myotis myotis). The iPSCs from both bat species showed similar characteristics and had a gene expression profile resembling that of cells attacked by viruses. They also had a high number of endogenous viral sequences, particularly retroviruses. These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences and may have a more intertwined relationship with viruses than previously thought. Further study of bat iPSCs and their differentiated progeny will provide insights into bat biology, virus host relationships, and the molecular basis of bats’ special traits.
DOI: 10.1016/j.cell.2023.01.011
Source: https://www.cell.com/cell/fulltext/S0092-8674(23)00041-7