南京大学Yun Xu和Yongbo Yang共同合作，近期取得重要工作进展。他们研究发现，GM-CSF促进Moyamoya病功能障碍血管网络的发展。相关研究成果研2023年12月19日在线发表于《神经科学通报》杂志上。

据介绍，Moyamoya病（MMD）是一种慢性闭塞性脑血管疾病，伴有血管网络异常。免疫炎症与MMD的发生和发展有关。然而，异常血管网络形成的机制尚不清楚。

本研究纳入了28例MMD患者、26例缺血性脑卒中患者和26名无关的健康志愿者。数据显示，MMD患者的粒细胞-巨噬细胞集落刺激因子（GM-CSF）水平高于健康对照组（P<0.01），并且GM-CSF主要来自MMD中的Th1和Th17细胞。研究人员发现，GM-CSF的增加驱动单核细胞分泌一系列与血管生成、炎症和趋化性相关的细胞因子。

总之，这一研究结果首次证明了GM-CSF在MMD中的重要作用，并且GM-CSF是MMD异常血管网络形成的重要因素。

附：英文原文

Title: GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease

Author: Li, Huiqin, Cao, Xiang, Gu, Xinya, Dong, Mengqi, Huang, Lili, Mao, Chenglu, Xia, Shengnan, Yang, Haiyan, Bao, Xinyu, Yang, Yongbo, Xu, Yun

Issue&Volume: 2023-12-19

Abstract: Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels. Immune inflammation is associated with the occurrence and development of MMD. However, the mechanisms underlying the formation of the abnormal vascular network remain unclear. Twenty-eight patients with MMD, 26 ischemic stroke patients, and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) were higher in MMD patients than in healthy controls (P <0.01), and GM-CSF was mainly from Th1 and Th17 cells in MMD. We found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis, inflammation, and chemotaxis. In summary, our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.

DOI: 10.1007/s12264-023-01158-y

Source: https://link.springer.com/article/10.1007/s12264-023-01158-y