法国索邦大学Alain Chédotal等研究人员合作绘制出发育中的人类头部三维图谱。该项研究成果于2023年12月8日在线发表在《细胞》杂志上。

研究人员利用先进的全装免疫染色和三维成像技术生成了人类头部胚胎发育的综合三维细胞图谱。研究人员展示了各种头部组织和细胞类型的详细发育系列，包括肌肉、血管、软骨、周围神经和外分泌腺。这些数据集可通过专门的网络界面访问，为人类胚胎发育提供了深入的见解。研究人员对人类外分泌腺的分支形态发生以及神经血管和骨骼肌肉结构发育的未知特征进行了透视。这些对人类胚胎学的见解对于了解颅面缺陷和神经系统疾病以及推进诊断和治疗策略具有重要意义。

据了解，长期以来，头部的演化和发育一直吸引着研究人员，因为头部是感官刺激的重要通道，而且头部的结构错综复杂。尽管在了解各种脊椎动物的头部发育方面已经取得了重大进展，但人们对人类早期头部发育的了解仍然有限。

附：英文原文

Title: A tridimensional atlas of the developing human head

Author: Raphael Blain, Gérard Couly, Eimad Shotar, Joséphine Blévinal, Maryne Toupin, Anais Favre, Ali Abjaghou, Megumi Inoue, Edwin Hernández-Garzón, Frédéric Clarenon, Frédéric Chalmel, Séverine Mazaud-Guittot, Paolo Giacobini, Yorick Gitton, Alain Chédotal

Issue&Volume: 2023-12-08

Abstract: The evolution and development of the head have long captivated researchers due to the crucial role of the head as the gateway for sensory stimuli and the intricate structural complexity of the head. Although significant progress has been made in understanding head development in various vertebrate species, our knowledge of early human head ontogeny remains limited. Here, we used advanced whole-mount immunostaining and 3D imaging techniques to generate a comprehensive 3D cellular atlas of human head embryogenesis. We present detailed developmental series of diverse head tissues and cell types, including muscles, vasculature, cartilage, peripheral nerves, and exocrine glands. These datasets, accessible through a dedicated web interface, provide insights into human embryogenesis. We offer perspectives on the branching morphogenesis of human exocrine glands and unknown features of the development of neurovascular and skeletomuscular structures. These insights into human embryology have important implications for understanding craniofacial defects and neurological disorders and advancing diagnostic and therapeutic strategies.

DOI: 10.1016/j.cell.2023.11.013

Source: https://www.cell.com/cell/fulltext/S0092-8674(23)01230-8