据介绍，成人神经干细胞（NSC）有助于终身大脑可塑性。在成年小鼠脑室-室下区，神经干细胞是异质性的，并且根据其在生态位中的位置，产生不同亚型的嗅球（OB）中间神经元。
研究人员发现多个区域性不同的NSC，包括通常静止的结构域，在妊娠的不同时间点被招募。这些成年NSC池的同步激活会产生短暂的OB中间神经元的瞬态波，尤其是在稳态下神经发生较少的层中。利用空间转录组学，研究人员鉴定了与妊娠相关中间神经元的分子标记，并表明一些亚群是识别幼崽所暂时需要的。
因此，妊娠触发了短暂但行为相关的神经发生，突出了成人干细胞异质性的生理相关性。
附：英文原文
Title: Pregnancy-responsive pools of adult neural stem cells for transient neurogenesis in mothers
Author: Zayna Chaker, Corina Segalada, Jonas A. Kretz, Ilhan E. Acar, Ana C. Delgado, Valerie Crotet, Andreas E. Moor, Fiona Doetsch
Issue&Volume: 2023-11-24
Abstract: Adult neural stem cells (NSCs) contribute to lifelong brain plasticity. In the adult mouse ventricular-subventricular zone, NSCs are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb (OB) interneurons. Here, we show that multiple regionally distinct NSCs, including domains that are usually quiescent, are recruited on different gestation days during pregnancy. Synchronized activation of these adult NSC pools generates transient waves of short-lived OB interneurons, especially in layers with less neurogenesis under homeostasis. Using spatial transcriptomics, we identified molecular markers of pregnancy-associated interneurons and showed that some subsets are temporarily needed for own pup recognition. Thus, pregnancy triggers transient yet behaviorally relevant neurogenesis, highlighting the physiological relevance of adult stem cell heterogeneity.
DOI: abo5199
Source: https://www.science.org/doi/10.1126/science.abo5199