研究人员报告了一种演化的种间通讯途径，涉及到一种被称为Dome1的Ixodes scapularis蜱虫中心受体，它获得了一种哺乳动物的细胞因子受体模体，对干扰素-γ（IFN-γ）表现出高亲和力。宿主产生的IFN-γ促进了Dome1介导的Ixodes JAK-STAT途径的激活。这加速了蜱虫血食的获取和发展，同时上调了抗菌成分。Dome1-JAK-STAT途径存在于大多数硬蜱的基因组中，调节肠道细胞的再生和增殖，包括干细胞，并通过Hedgehog和Notch-Delta网络决定变态，最终影响硬蜱的媒介竞争。研究人员强调了Ixodes scapularis对哺乳动物宿主的演化依赖性，它通过跨物种的信号传导机制同时影响节肢动物的免疫和发育。
据了解，祖先信号通路在后生动物发育、生理和免疫中起着关键作用。
附：英文原文
Title: Dome1–JAK–STAT signaling between parasite and host integrates vector immunity and development
Author: Vipin S. Rana, Chrysoula Kitsou, Shraboni Dutta, Michael H. Ronzetti, Min Zhang, Quentin Bernard, Alexis A. Smith, Julen Tomás-Cortázar, Xiuli Yang, Ming-Jie Wu, Oleksandra Kepple, Weizhong Li, Jennifer E. Dwyer, Jaqueline Matias, Bolormaa Baljinnyam, Jonathan D. Oliver, Nallakkandi Rajeevan, Joao H F Pedra, Sukanya Narasimhan, Yan Wang, Ulrike Munderloh, Erol Fikrig, Anton Simeonov, Juan Anguita, Utpal Pal
Issue&Volume: 2023-01-13
Abstract: Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-γ). Host-derived IFN-γ facilitates Dome1-mediated activation of the Ixodes JAK–STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1–JAK–STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells—including stem cells—and dictates metamorphosis through the Hedgehog and Notch–Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
DOI: abl3837
Source: https://www.science.org/doi/10.1126/science.abl3837