近日，美国德克萨斯大学Na Xiong及其研究组发现，iNKT细胞在发育过程中的早期皮肤定位支持局部组织的发育和稳态。相关论文于2023年1月9日在线发表在《自然—免疫学》杂志上。

据了解，皮肤暴露在各种环境攻击下，出生后立即发生形态变化。免疫细胞在皮肤中的正确定位和功能对于保护和建立皮肤组织的平衡至关重要。

附：英文原文

Title: Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis

Author: Wang, Wei-Bei, Lin, Yang-Ding, Zhao, Luming, Liao, Chang, Zhang, Yang, Davila, Micha, Sun, Jasmine, Chen, Yidong, Xiong, Na

Issue&Volume: 2023-01-09

Abstract: Skin is exposed to various environmental assaults and undergoes morphological changes immediately after birth. Proper localization and function of immune cells in the skin is crucial for protection and establishment of skin tissue homeostasis. Here we report the discovery of a developmentally programmed process that directs preferential localization of invariant natural killer T (iNKT) cells to the skin for early local homeostatic regulation. We show that iNKT cells are programmed predominantly with a CCR10+ skin-homing phenotype during thymic development in infant and young mice. Early skin localization of iNKT cells is critical for proper commensal bacterial colonization and tissue development. Mechanistically, skin iNKT cells provide a local source of transferrin that regulates iron metabolism in hair follicle progenitor cells and helps hair follicle development. These findings provide molecular insights into the establishment and physiological functions of iNKT cells in the skin during early life.

DOI: 10.1038/s41590-022-01399-5

Source: https://www.nature.com/articles/s41590-022-01399-5