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小鼠视觉皮层声诱发活动的行为来源
作者:小柯机器人 发布时间:2023/1/10 16:42:20

英国伦敦大学学院Célian Bimbard团队发现小鼠视觉皮层声诱发活动的行为来源。这一研究成果于2023年1月9日发表在国际顶尖学术期刊《自然—神经科学》上。

他们展示了用神经像素探针测量的初级视觉皮层(V1)中由声音引起的活动,在神经元甚至在小鼠中都是定型的。它独立于听觉皮层的投射,类似于在接受很少直接听觉输入的海马体中唤起的活动。它的低维特性与V1用来表示图像的高维代码形成鲜明对比。此外,这种声音诱发的活动可以通过由每种声音引起的微小身体运动精确预测,并且在试验和小鼠中具有模式化。因此,明显的多感官的神经活动可能只是来自与内部状态和行为相关的低维信号。

据了解,感觉皮层可以受到多种模式刺激的影响,因此越来越多地被认为是多感觉的。例如, V1不仅受到图像的影响,还受到声音的影响。

附:英文原文

Title: Behavioral origin of sound-evoked activity in mouse visual cortex

Author: Bimbard, Clian, Sit, Timothy P. H., Lebedeva, Anna, Reddy, Charu B., Harris, Kenneth D., Carandini, Matteo

Issue&Volume: 2023-01-09

Abstract: Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly thought to be multisensory. For instance, primary visual cortex (V1) is influenced not only by images but also by sounds. Here we show that the activity evoked by sounds in V1, measured with Neuropixels probes, is stereotyped across neurons and even across mice. It is independent of projections from auditory cortex and resembles activity evoked in the hippocampal formation, which receives little direct auditory input. Its low-dimensional nature starkly contrasts the high-dimensional code that V1 uses to represent images. Furthermore, this sound-evoked activity can be precisely predicted by small body movements that are elicited by each sound and are stereotyped across trials and mice. Thus, neural activity that is apparently multisensory may simply arise from low-dimensional signals associated with internal state and behavior.

DOI: 10.1038/s41593-022-01227-x

Source: https://www.nature.com/articles/s41593-022-01227-x

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:28.771
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex