美国哥伦比亚大学
为了重建四肢动物的前脑演化，研究人员建立了蝾螈端脑的一个细胞类型图谱。这些分子、发育和连接数据表明，蜥蜴类的部分背侧室脊（DVR）可以追溯到四足动物的祖先。相比之下，蝾螈的背侧皮层没有哺乳动物新皮层的细胞和分子特征，但与内嗅皮层和下托有相似之处。这些发现描绘了导致哺乳动物六层新皮层和蜥蜴类DVR出现的一系列创新。
据悉，脊椎动物高级认知的演化与前脑的两个独立创新有关：哺乳动物的六层新皮层和蜥蜴类（爬行动物和鸟类）的DVR。这些创新是如何在脊椎动物的祖先中产生的仍然不清楚。
附：英文原文
Title: Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution
Author: Jamie Woych, Alonso Ortega Gurrola, Astrid Deryckere, Eliza C. B. Jaeger, Elias Gumnit, Gianluca Merello, Jiacheng Gu, Alberto Joven Araus, Nicholas D. Leigh, Maximina Yun, András Simon, Maria Antonietta Tosches
Issue&Volume: 2022-09-02
Abstract: The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander Pleurodeles waltl. Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR.
DOI: abp9186
Source: https://www.science.org/doi/10.1126/science.abp9186