法国巴黎萨克莱神经科学研究所Brice Bathellier和Alain Destexhe共同合作近期取得重要工作进展，他们研究发现清醒的知觉与大脑皮层中的专用神经元集群有关。相关论文2022年9月28日在线发表于《自然—神经科学》杂志上。

研究人员在小鼠中证明，在清醒状态下，听觉皮层和丘脑中由声音诱发的神经元集群对刺激是特定的，与在持续活动中观察到的集群不同。相比之下，在三种不同的麻醉药下，皮层中诱发的集合与正在进行的集群没有区别。

然而，它们在丘脑中仍然是不同的。伴随着麻醉产生的这种动态变化，强烈的感觉反应重新映射。综上所述，清醒的大脑皮层对感觉输入的反应是专门的神经元集群。研究人员认为这是一个与感觉知觉相关的网络。

据介绍，清醒的知觉与大脑皮层中的专用神经元集群有关感觉皮层中的神经活动，结合了刺激反应和正在进行的活动，但仍不清楚这些活动是反映相同的基本动态还是独立的过程。

附：英文原文

Title: Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex

Author: Filipchuk, Anton, Schwenkgrub, Joanna, Destexhe, Alain, Bathellier, Brice

Issue&Volume: 2022-09-28

Abstract: Neural activity in the sensory cortex combines stimulus responses and ongoing activity, but it remains unclear whether these reflect the same underlying dynamics or separate processes. In the present study, we show in mice that, during wakefulness, the neuronal assemblies evoked by sounds in the auditory cortex and thalamus are specific to the stimulus and distinct from the assemblies observed in ongoing activity. By contrast, under three different anesthetics, evoked assemblies are indistinguishable from ongoing assemblies in the cortex. However, they remain distinct in the thalamus. A strong remapping of sensory responses accompanies this dynamic state change produced by anesthesia. Together, these results show that the awake cortex engages dedicated neuronal assemblies in response to sensory inputs, which we suggest is a network correlate of sensory perception.

DOI: 10.1038/s41593-022-01168-5

Source: https://www.nature.com/articles/s41593-022-01168-5