厦门大学林泓域团队报道了¹⁹F条形码实现与器官损伤和癌症相关的生物标志物的多重检测。相关研究成果发表在2022年9月19日出版的《德国应用化学》。

在复杂环境中同时检测多种生物标记物对于深入探索不同的生物过程至关重要，由于各种限制，这对许多当前的分析方法来说都是一个挑战。

该文中，研究人员报告了一种¹⁹F条形码策略，该策略利用了¹⁹F的高磁共振（MR）灵敏度、对环境变化的快速信号响应、可忽略的生物背景、定量信号输出和多路传输能力等优点。设计、合成并表征了一组¹⁹F条形码传感器，用于响应与器官损伤和癌症相关的不同生物标记物。利用这些传感器可以同时评估从药物引起的肝/肾损伤或肿瘤小鼠中采集的样本中的不同生物标记物，表明了这种方法在各种生物过程的复杂环境中多重检测不同生物标记的可行性。

附：英文原文

Title: 19F Barcoding Enables Multiplex Detection of Biomarkers Associated with Organ Injury and Cancer

Author: Xiangjie Luo, Bilun Kang, Xiaoqin Chi, Hui Xiong, Dongxia Chen, Yifan Fan, Lingxuan Li, Limin Chen, Ao Li, Jinhao Gao, Hongyu Lin

Issue&Volume: 2022-09-19

Abstract: Simultaneous detection of multiple biomarkers in complex environments is critical for the in-depth exploration of different biological processes, which is challenging for many current analytical methods due to various limitations. Herein, we report a strategy of 19F barcoding which takes the advantages of 19F's high magnetic resonance (MR) sensitivity, prompt signal response to environmental changes, negligible biological background, quantitative signal output, and multiplex capacity. A set of 19F-barcoded sensors responding to different biomarkers involved in organ injury and cancer are designed, synthesized, and characterized. With these sensors, we accomplish concurrent assessment of different biomarkers in the samples collected from the mice with drug-induced liver/kidney injury or tumor, illustrating the feasibility of this approach for multiplexed detection of different biomarkers in complex environments during various biological processes.

DOI: 10.1002/anie.202211189

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202211189