瑞典隆德大学Joan Yuan团队近期取得重要工作进展，他们研究发现生命早期起源B细胞的自我维持层驱动成人肠道中稳态的IgA反应。相关研究成果2022年9月16日在线发表于《免疫》杂志。

研究人员想确定在不受干扰的造血过程中发育起源与成人B细胞池组成之间的关系。谱系追踪根据输出时间对鼠成体B细胞进行分层，揭示了很大一部分起源于受限的新生儿窗口。除了B-1a细胞外，生命早期有时间戳的B细胞还包括肠道和骨髓中的克隆相关IgA浆细胞。这些由肠道慢性生发中心内的B细胞记忆积极维持的，并包含共生微生物群反应性。新生儿轮状病毒感染招募了复发的IgA克隆，这些克隆与成人感染相同抗原所产生的IgA克隆不同。最后，在个体发育过程中，肠道IgA浆细胞来自与B-1a细胞相同的造血祖细胞。因此，新生儿印记的B细胞的复杂层在生命后期赋予了独特的抗体反应。

据介绍，成人免疫系统由个体发育过程中不同时期出现的细胞组成。

附：英文原文

Title: A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

Author: Stefano Vergani, Konjit Getachew Muleta, Clément Da Silva, Alexander Doyle, Trine Ahn Kristiansen, Selene Sodini, Niklas Krausse, Giorgia Montano, Knut Kotarsky, Joy Nakawesi, Hugo kerstrand, Stijn Vanhee, Sneh Lata Gupta, David Bryder, William Winston Agace, Katharina Lahl, Joan Yuan

Issue&Volume: 2022-09-16

Abstract: The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addition to B-1a cells, early-life time-stamped B cells included clonally interrelated IgA plasma cells in the gut and bone marrow. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal microbiota reactivity. Neonatal rotavirus infection recruited recurrent IgA clones that were distinct from those arising by infection with the same antigen in adults. Finally, gut IgA plasma cells arose from the same hematopoietic progenitors as B-1a cells during ontogeny. Thus, a complex layer of neonatally imprinted B cells confer unique antibody responses later in life.

DOI: 10.1016/j.immuni.2022.08.018

Source: https://www.cell.com/immunity/fulltext/S1074-7613(22)00412-5