德国朱利叶斯-马克西米利安大学Wolfgang Kastenmüller和Marco A. Ataide共同合作近期取得重要工作进展，他们研究发现非常规T细胞的淋巴迁移促进不同淋巴结的位点特异性免疫。相关研究成果2022年8月23日在线发表于《免疫学》杂志上。

通过使用单一UTC谱系缺陷小鼠模型，研究人员发现UTC在相互连接的单元中功能合作，并产生和形成特征性的先天和适应性免疫反应，这些反应在排出不同组织的LN之间是不同的。因此，UTC的淋巴迁移是在不同LNs中引发的位点特异性免疫的关键决定因素，对疫苗接种策略和免疫治疗方法具有潜在影响。

据介绍，分子的淋巴转运和骨髓细胞向淋巴结（LN）的迁移不断地告知淋巴细胞引流组织的变化。研究人员使用LN移植、单细胞RNA-seq、光谱流式细胞术和用于光标记的转基因小鼠模型，发现组织来源的非常规T细胞（UTCs）通过淋巴途径迁移到局部引流的LNs。由于每个组织都具有独特的UTCs谱，具有局部适应的分化状态和不同的T细胞受体库，因此每个引流LN都由独特组织决定的淋巴细胞混合物组成。

附：英文原文

Title: Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

Author: Marco A. Ataide, Konrad Knpper, Paulina Cruz de Casas, Milas Ugur, Sarah Eickhoff, Mangge Zou, Haroon Shaikh, Apurwa Trivedi, Anika Grafen, Tao Yang, Immo Prinz, Knut Ohlsen, Mercedes Gomez de Agüero, Andreas Beilhack, Jochen Huehn, Mauro Gaya, Antoine-Emmanuel Saliba, Georg Gasteiger, Wolfgang Kastenmüller

Issue&Volume: 2022-08-23

Abstract: Lymphatic transport of molecules and migration of myeloid cells to lymph nodes (LNs)continuously inform lymphocytes on changes in drained tissues. Here, using LN transplantation,single-cell RNA-seq, spectral flow cytometry, and a transgenic mouse model for photolabeling,we showed that tissue-derived unconventional T cells (UTCs) migrate via the lymphaticroute to locally draining LNs. As each tissue harbored a distinct spectrum of UTCswith locally adapted differentiation states and distinct T cell receptor repertoires,every draining LN was thus populated by a distinctive tissue-determined mix of theselymphocytes. By making use of single UTC lineage-deficient mouse models, we foundthat UTCs functionally cooperated in interconnected units and generated and shapedcharacteristic innate and adaptive immune responses that differed between LNs thatdrained distinct tissues. Lymphatic migration of UTCs is, therefore, a key determinantof site-specific immunity initiated in distinct LNs with potential implications forvaccination strategies and immunotherapeutic approaches.

DOI: 10.1016/j.immuni.2022.07.019

Source: https://www.cell.com/immunity/fulltext/S1074-7613(22)00354-5