当前位置:科学网首页 > 小柯机器人 >详情
多模态感知将细胞状态与单细胞的决策联系起来
作者:小柯机器人 发布时间:2022/7/17 17:12:43

瑞士苏黎世大学Lucas Pelkmans研究小组发现,多模态感知将细胞状态与单细胞的决策联系起来。相关论文于2022年7月14日在线发表在《科学》杂志上。

利用信号反应和细胞状态的标记物的多重量化,研究人员发现网络中的信号节点显示出适应性的信息处理,这导致了异质性的生长因子反应,并使节点能够捕获关于细胞状态的部分非冗余信息。

总的来说,作为一个多模态的感知,这使单个细胞具有很大的信息处理能力,可以准确地将生长因子浓度置于其细胞状态的背景下,并做出与细胞状态相关的决定。研究人员提出,信号网络的异质性和复杂性已经共同进化,以便在多细胞环境中实现特定的和有背景意识的细胞决策。

据了解,单个细胞做出适应其内部状态和周围环境的决定,但细胞如何能可靠地做到这一点仍不清楚。

附:英文原文

Title: Multimodal perception links cellular state to decision making in single cells

Author: Bernhard A. Kramer, Jacobo Sarabia del Castillo, Lucas Pelkmans

Issue&Volume: 2022-07-14

Abstract: Individual cells take decisions that are adapted to their internal state and surroundings, but how cells can reliably do this remains unclear. Using multiplexed quantification of signaling responses and markers of the cellular state, we find that signaling nodes in a network display adaptive information processing, which leads to heterogeneous growth factor responses and enables nodes to capture partially non-redundant information about the cellular state. Collectively, as a multimodal percept, this gives individual cells a large information processing capacity to accurately place growth factor concentration within the context of their cellular state and make cellular state-dependent decisions. We propose that heterogeneity and complexity in signaling networks have co-evolved to enable specific and context-aware cellular decision making in a multicellular setting.

DOI: abf4062

Source: https://www.science.org/doi/10.1126/science.abf4062

 

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037