研究人员记录了清醒小鼠CA1海马中已识别的中间神经元的活动。 神经胶质细胞 （NGFC）——为锥体细胞的远端树突提供GABA能抑制——将它们的发射与那些使局部网络与皮质输入同步的伽马振荡紧密相连。NGFC的动作电位并没有加强这种同步性，而是将锥体细胞活动与皮质伽马振荡分离，但没有减少它们的放电，也没有影响局部振荡。 因此，NGFC通过暂时解除同步而不降低通信网络的活动来调节信息传输。
据介绍，跨大脑区域的有效交流需要分布的神经元网络动态同步或解耦它们正在进行的活动。GABA能中间神经元将集合锁定到网络振荡上，但关于同步性如何主动脱离以允许新的通信伙伴的问题仍然存在。
附：英文原文
Title: Neurogliaform cells dynamically decouple neuronal synchrony between brain areas
Author: Ece Sakalar, Thomas Klausberger, Bálint Lasztóczi
Issue&Volume: 2022-07-15
Abstract: Effective communication across brain areas requires distributed neuronal networks to dynamically synchronize or decouple their ongoing activity. GABAergic interneurons lock ensembles to network oscillations, but there remain questions regarding how synchrony is actively disengaged to allow for new communication partners. We recorded the activity of identified interneurons in the CA1 hippocampus of awake mice. Neurogliaform cells (NGFCs)—which provide GABAergic inhibition to distal dendrites of pyramidal cells—strongly coupled their firing to those gamma oscillations synchronizing local networks with cortical inputs. Rather than strengthening such synchrony, action potentials of NGFCs decoupled pyramidal cell activity from cortical gamma oscillations but did not reduce their firing nor affect local oscillations. Thus, NGFCs regulate information transfer by temporarily disengaging the synchrony without decreasing the activity of communicating networks.
DOI: abo3355
Source: https://www.science.org/doi/10.1126/science.abo3355