研究人员报告了聚焦旋转喷射纺丝（FRJS），这是一种增材制造方法，可以快速制造具有3D几何形状具有可编程排列的微/纳米纤维支架。在这些支架上植入心肌细胞可以实现组织工程心室的生物制造，与圆周排列相比，螺旋排列的模型显示出更均匀的变形、更大的心尖缩短和增加的射血分数。FRJS在三维空间上控制纤维排列的能力为制造组织和器官提供了一种简化的方法，这项工作展示了螺旋结构对心脏性能的贡献。
据推测，心脏肌肉组织内的螺旋排列对实现生理性的泵送效率非常重要。然而，测试这种可能性是困难的，因为使用当前技术再现心脏肌肉组织的精细空间特征和复杂结构具有挑战性。
附：英文原文
Title: Recreating the heart’s helical structure-function relationship with focused rotary jet spinning
Author: Huibin Chang, Qihan Liu, John F. Zimmerman, Keel Yong Lee, Qianru Jin, Michael M. Peters, Michael Rosnach, Suji Choi, Sean L. Kim, Herdeline Ann M. Ardoa, Luke A. MacQueen, Christophe O. Chantre, Sarah E. Motta, Elizabeth M. Cordoves, Kevin Kit Parker
Issue&Volume: 2022-07-08
Abstract: Helical alignments within the heart’s musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this possibility is difficult, however, because it is challenging to reproduce the fine spatial features and complex structures of the heart’s musculature using current techniques. Here we report focused rotary jet spinning (FRJS), an additive manufacturing approach that enables rapid fabrication of micro/nanofiber scaffolds with programmable alignments in three-dimensional geometries. Seeding these scaffolds with cardiomyocytes enabled the biofabrication of tissue-engineered ventricles, with helically aligned models displaying more uniform deformations, greater apical shortening, and increased ejection fractions compared with circumferential alignments. The ability of FRJS to control fiber arrangements in three dimensions offers a streamlined approach to fabricating tissues and organs, with this work demonstrating how helical architectures contribute to cardiac performance.
DOI: abl6395
Source: https://www.science.org/doi/10.1126/science.abl6395