英国布里斯托大学Christina Dardani等研究人员揭示父母炎症性肠病与儿童自闭症的关联。这一研究成果于2022年6月2日在线发表在国际学术期刊《自然—医学》上。

研究人员进行了四项补充研究来调查父母的炎症性肠病（IBD）与儿童自闭症之间的关联，并阐明其基本病因。研究人员利用瑞典登记册进行了一项全国性的基于人口的队列研究，发现了父母诊断的IBD与儿童自闭症之间的关联证据。对雅芳父母与儿童纵向研究的多基因风险评分分析表明，母亲的IBD遗传易感性与儿童的自闭症特征之间存在关联。

双样本孟德尔随机化分析提供了IBD（尤其是溃疡性结肠炎）遗传易感性对自闭症的潜在因果效应的证据。连锁不平衡得分回归没有表明IBD和自闭症之间的遗传相关性。从这四种互补的方法中，研究人员发现了父母，特别是母亲的IBD与儿童自闭症之间的潜在因果关系的证据。围产期免疫失调、微量营养素吸收不良和贫血可能与此有关。

据了解，将父母的IBD与儿童的自闭症联系起来的证据并不确定。

附：英文原文

Title: Parental inflammatory bowel disease and autism in children

Author: Sadik, Aws, Dardani, Christina, Pagoni, Panagiota, Havdahl, Alexandra, Stergiakouli, Evie, Khandaker, Golam M., Sullivan, Sarah A., Zammit, Stan, Jones, Hannah J., Davey Smith, George, Dalman, Christina, Karlsson, Hkan, Gardner, Renee M., Rai, Dheeraj

Issue&Volume: 2022-06-02

Abstract: Evidence linking parental inflammatory bowel disease (IBD) with autism in children is inconclusive. We conducted four complementary studies to investigate associations between parental IBD and autism in children, and elucidated their underlying etiology. Conducting a nationwide population-based cohort study using Swedish registers, we found evidence of associations between parental diagnoses of IBD and autism in children. Polygenic risk score analyses of the Avon Longitudinal Study of Parents and Children suggested associations between maternal genetic liability to IBD and autistic traits in children. Two-sample Mendelian randomization analyses provided evidence of a potential causal effect of genetic liability to IBD, especially ulcerative colitis, on autism. Linkage disequilibrium score regression did not indicate a genetic correlation between IBD and autism. Triangulating evidence from these four complementary approaches, we found evidence of a potential causal link between parental, particularly maternal, IBD and autism in children. Perinatal immune dysregulation, micronutrient malabsorption and anemia may be implicated. Evidence from four complementary methodological approaches, harnessing genotype and phenotype data, identifies potential causal links between inflammatory bowel disease in parents and autism in children.

DOI: 10.1038/s41591-022-01845-9

Source: https://www.nature.com/articles/s41591-022-01845-9