近日，瑞士苏黎世联邦理工学院Pierre-Alain Clavien等研究人员实现离体常温保存3天后的人类肝移植。该研究于2022年5月31日在线发表于国际一流学术期刊《自然—生物技术》。

Author: Clavien, Pierre-Alain, Dutkowski, Philipp, Mueller, Matteo, Eshmuminov, Dilmurodjon, Bautista Borrego, Lucia, Weber, Achim, Muellhaupt, Beat, Sousa Da Silva, Richard X., Burg, Brian R., Rudolf von Rohr, Philipp, Schuler, Martin J., Becker, Dustin, Hefti, Max, Tibbitt, Mark W.

Issue&Volume: 2022-05-31

Abstract: Current organ preservation methods provide a narrow window (usually <12hours) to assess, transport and implant donor grafts for human transplantation. Here we report the transplantation of a human liver discarded by all centers, which could be preserved for several days using ex situ normothermic machine perfusion. The transplanted liver exhibited normal function, with minimal reperfusion injury and the need for only a minimal immunosuppressive regimen. The patient rapidly recovered a normal quality of life without any signs of liver damage, such as rejection or injury to the bile ducts, according to a 1-year follow up. This inaugural clinical success opens new horizons in clinical research and promises an extended time window of up to 10days for assessment of viability of donor organs as well as converting an urgent and highly demanding surgery into an elective procedure.

DOI: 10.1038/s41587-022-01354-7

Source: https://www.nature.com/articles/s41587-022-01354-7