近日，法国艾克斯马赛大学Mauro Gaya、Pierre Milpied等研究人员合作发现，病毒感染通过一种许可机制产生不同的肺驻留记忆B细胞亚群。2022年6月28日，国际知名学术期刊《免疫》在线发表了这一成果。

Title: Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism

Author: Claude Gregoire, Lionel Spinelli, Sergio Villazala-Merino, Laurine Gil, María Pía Holgado, Myriam Moussa, Chuang Dong, Ana Zarubica, Mathieu Fallet, Jean-Marc Navarro, Bernard Malissen, Pierre Milpied, Mauro Gaya

Issue&Volume: 2022-06-28

Abstract: Lung-resident memory B cells (MBCs) provide localized protection against reinfectionin respiratory airways. Currently, the biology of these cells remains largely unexplored.Here, we combined influenza and SARS-CoV-2 infection with fluorescent-reporter miceto identify MBCs regardless of antigen specificity. We found that two main transcriptionallydistinct subsets of MBCs colonized the lung peribronchial niche after infection. Thesesubsets arose from different progenitors and were both class switched, somaticallymutated, and intrinsically biased in their differentiation fate toward plasma cells.Combined analysis of antigen specificity and B cell receptor repertoire segregatedthese subsets into “bona fide” virus-specific MBCs and “bystander” MBCs with no apparentspecificity for eliciting viruses generated through an alternative permissive process.Thus, diverse transcriptional programs in MBCs are not linked to specific effectorfates but rather to divergent strategies of the immune system to simultaneously providerapid protection from reinfection while diversifying the initial B cell repertoire.

DOI: 10.1016/j.immuni.2022.06.002

Source: https://www.cell.com/immunity/fulltext/S1074-7613(22)00240-0