美国德克萨斯大学西南医学中心Joseph S. Takahashi和Carla B. Green研究组合作发现，早发性热量限制 (CR)的昼夜节律调整可促进雄性 C57BL/6J 小鼠的寿命。2022年5月5日出版的《科学》杂志发表了这项成果。

在 CR 下，小鼠会自我实施 2 小时喂食和 22 小时禁食的慢性循环，这引发了热量、禁食或一天中的时间是否是因果关系的问题。他们表明 30%-CR 足以将寿命延长 10%；然而，每日禁食间隔和昼夜节律调整共同作用可将雄性 C57BL/6J 小鼠的寿命延长 35%。

这些影响与体重无关。衰老会导致与炎症相关的基因表达普遍增加，并且在随意喂食的小鼠肝脏中编码代谢途径成分的基因表达减少。夜间 CR 可改善这些与衰老相关的变化。因此，昼夜节律干预可促进长寿，并为进一步探索衰老机制提供了视角。

研究人员表示，CR可以延长寿命，但其这样做的机制仍然知之甚少。

附：英文原文

Title: Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Author: Victoria Acosta-Rodríguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green, Joseph S. Takahashi

Issue&Volume: 2022-05-05

Abstract: Caloric restriction (CR) prolongs lifespan, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour-feeding and 22-hour-fasting, raising the question whether calories, fasting, or time of day are causal. We show that 30%-CR is sufficient to extend lifespan 10%; however, a daily fasting interval and circadian-alignment of feeding act together to extend lifespan 35% in male C57BL/6J mice. These effects are independent of body weight. Aging induces widespread increases in gene expression associated with inflammation and decreases in expression of genes encoding components of metabolic pathways in liver from ad lib fed mice. CR at night ameliorates these aging-related changes. Thus, circadian interventions promote longevity and provide a perspective to further explore mechanisms of aging.

DOI: abk0297

Source: https://www.science.org/doi/10.1126/science.abk0297