国家纳米科学与技术中心的Chunying Chen研究团队近日综述了纳米药物中蛋白冠的化学和生物物理特征。相关论文发表在2022年5月10日出版的《美国化学会杂志》上。

在纳米药物中，蛋白冠是一个非常棘手的阻碍，这是生命系统中纳米颗粒对生物分子的一种自发收集机制。蛋白冠在组成上是动态的，它可能会改善纳米颗粒在水中的可悬浊性，并降低纳米颗粒的递送效率和靶向性。

这种非特异蛋白复合物有多少是由纳米颗粒核心的化学性质及其表面功能化决定的？又有多少是由体内时空变化的生物环境决定的？如何在不显著牺牲纳米药物诊断和治疗人类疾病功效的前提下，与蛋白冠“共存”并加以利用？这篇文章论述了蛋白冠的化学和生物物理特征，并对纳米药物领域面临的以上挑战进行了思考。

附：英文原文

Title: Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

Author: Jiayu Ren, Nicholas Andrikopoulos, Kelly Velonia, Huayuan Tang, Rong Cai, Feng Ding, Pu Chun Ke, Chunying Chen

Issue&Volume: May 10, 2022

Abstract: An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous collection of biomolecular species by nanoparticles in living systems. The protein corona is dynamic in composition and may entail improved water suspendability and compromised delivery and targeting to the nanoparticles. How much of this nonspecific protein ensemble is determined by the chemistry of the nanoparticle core and its surface functionalization, and how much of this entity is dictated by the biological environments that vary spatiotemporally in vivo？How do we “live with” and exploit the protein corona without significantly sacrificing the efficacy of nanomedicines in diagnosing and curing human diseases？This article discusses the chemical and biophysical signatures of the protein corona and ponders challenges ahead for the field of nanomedicine.

DOI: 10.1021/jacs.2c02277

Source: https://pubs.acs.org/doi/10.1021/jacs.2c02277