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组织中的细胞分裂使巨噬细胞得以浸润
作者:小柯机器人 发布时间:2022/4/24 16:48:29

奥地利科技研究所Daria E. Siekhaus、Maria Akhmanova等研究人员合作发现,组织中的细胞分裂使巨噬细胞得以浸润。2022年4月21日出版的《科学》杂志发表了这项成果。

研究人员发现,果蝇巨噬细胞对胚胎组织的入侵需要在进入部位分裂一个上皮外胚层细胞。分裂的外胚层细胞分解了中胚层细胞旁边由整合素介导的局灶性粘附所形成的细胞外基质(ECM)附着物,使巨噬细胞能够将其细胞核向前移动,侵入两个紧邻的组织之间。侵入效率取决于分裂频率,但粘附强度的降低使巨噬细胞的进入不受分裂影响。

这项工作表明,组织动态可以调节细胞的浸润。

据介绍,细胞在正常发育、免疫反应和癌症转移过程中通过组织内拥挤的微环境进行迁移。虽然通过ECM中孔隙和轨道的迁移已经得到了很好的研究,但对细胞穿越到封闭的细胞密集的组织中却知之甚少。

附:英文原文

Title: Cell division in tissues enables macrophage infiltration

Author: Maria Akhmanova, Shamsi Emtenani, Daniel Krueger, Attila Gyoergy, Mariana Guarda, Mikhail Vlasov, Fedor Vlasov, Andrei Akopian, Aparna Ratheesh, Stefano De Renzis, Daria E. Siekhaus

Issue&Volume: 2022-04-22

Abstract: Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration through pores and tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by Drosophila macrophages requires division of an epithelial ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues. Invasion efficiency depends on division frequency, but reduction of adhesion strength allows macrophage entry independently of division. This work demonstrates that tissue dynamics can regulate cellular infiltration.

DOI: abj0425

Source: https://www.science.org/doi/10.1126/science.abj0425

 

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037