研究人员考虑心脏的两个功能调节特征（机械电信号和自动性）是否可以转移到另一个流体运输系统的合成类似物：游泳的鱼。通过利用心脏的机械电信号，研究人员在一个肌肉双层结构中重新创建了相互收缩和放松，其中每个收缩都是作为对拮抗肌肉对拉伸的反应而自动发生的。
此外，为了诱导这个闭环驱动循环，研究人员设计了一个电自主起搏节点，这增强了自发收缩。配备内在控制策略的生物杂交鱼展示了自我维持的身体——尾鳍游泳，这突出了反馈机制在肌肉泵（如心脏和肌肉）中的作用。
据了解，为了更好地理解生物系统的设计原理和协调机制，生物杂交系统已经被开发出来。
附：英文原文
Title: An autonomously swimming biohybrid fish designed with human cardiac biophysics
Author: Keel Yong Lee, Sung-Jin Park, David G. Matthews, Sean L. Kim, Carlos Antonio Marquez, John F. Zimmerman, Herdeline Ann M. Ardoa, Andre G. Kleber, George V. Lauder, Kevin Kit Parker
Issue&Volume: 2022-02-11
Abstract: Biohybrid systems have been developed to better understand the design principles and coordination mechanisms of biological systems. We consider whether two functional regulatory features of the heart—mechanoelectrical signaling and automaticity—could be transferred to a synthetic analog of another fluid transport system: a swimming fish. By leveraging cardiac mechanoelectrical signaling, we recreated reciprocal contraction and relaxation in a muscular bilayer construct where each contraction occurs automatically as a response to the stretching of an antagonistic muscle pair. Further, to entrain this closed-loop actuation cycle, we engineered an electrically autonomous pacing node, which enhanced spontaneous contraction. The biohybrid fish equipped with intrinsic control strategies demonstrated self-sustained body–caudal fin swimming, highlighting the role of feedback mechanisms in muscular pumps such as the heart and muscles.
DOI: abh0474
Source: https://www.science.org/doi/10.1126/science.abh0474