上海交通大学Ke Tao研究团队近日取得一项新成果。经过不懈努力，他们开发出近红外（NIR）光激发氧化铥纳米颗粒产生活性氧（ROS）的方法。相关论文于2022年2月4日发表在《美国化学会杂志》上。

在该文中，课题组研究人员证明了氧化铥纳米颗粒可以通过NIR刺激产生ROS。这可能与铥离子独特的能级、较大的吸收截面、较低的荧光发射和其³H₄态约10^-3 s的寿命有关。课题组人员进一步证明了这些纳米粒子对光动力疗法（PDT）的影响，在该过程中，在宽带卤素灯或808 nm激光照射下该纳米粒子表现出令人印象深刻的肿瘤抑制活性。该研究结果可能为光催化、污染处理和精细化学合成等领域提供见解。

研究人员表示，探索能够吸收近红外光产生活性氧的材料是许多领域的需要。

附：英文原文

Title: Near-Infrared Light-Excited Reactive Oxygen Species Generation by Thulium Oxide Nanoparticles

Author: Dida Duosiken, Ruihao Yang, Yingfan Dai, Zeinab Marfavi, Quanjie Lv, Hanyin Li, Kang Sun, Ke Tao

Issue&Volume: February 4, 2022

Abstract: Exploring materials that can absorb near-infrared (NIR) light to produce reactive oxygen species (ROS) is necessary for many fields. Herein we show that thulium oxide nanoparticles are viable for NIR-stimulated ROS generation. This property may be related to the unique energy levels, large absorption cross section, low fluorescence emission, and ～10–3 s lifetime of the 3H4 state of Tm ions. We further demonstrate the impact of these nanoparticles on photodynamic therapy (PDT), in which impressive tumor inhibition was recorded after exposure to either a broadband halogen lamp or an 808 nm laser. Our results may provide insight into the areas of photocatalysis, pollution treatment, and fine chemical synthesis.

DOI: 10.1021/jacs.1c11704

Source: https://pubs.acs.org/doi/10.1021/jacs.1c11704