北京大学詹启敏等研究人员合作利用综合多组学分析揭示出一个与临床相关的食管鳞状细胞癌分子分类。这一研究成果于2022年12月29日在线发表在国际学术期刊《癌细胞》上。

Title: Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma

Author: Zhihua Liu, Yahui Zhao, Pengzhou Kong, Yuhao Liu, Jing Huang, Enwei Xu, Wenqing Wei, Guangyu Li, Xiaolong Cheng, Liyan Xue, Yi Li, Hongyan Chen, Shuqing Wei, Ruifang Sun, Heyang Cui, Yongsheng Meng, Meilin Liu, Yang Li, Riyue Feng, Xiao Yu, Rui Zhu, Yenan Wu, Lei Li, Bin Yang, Yanchun Ma, Jiawei Wang, Wenjie Zhu, Dongjie Deng, Yanfeng Xi, Fang Wang, Hongyi Li, Shiping Guo, Xiaofei Zhuang, Xiaoyue Wang, Yuchen Jiao, Yongping Cui, Qimin Zhan

Issue&Volume: 2022-12-29

Abstract: Integrated molecular analysis of human cancer has yielded molecular classificationfor precise management of cancer patients. Here, we analyzed the whole genomic, epigenomic,transcriptomic, and proteomic data of 155 esophageal squamous cell carcinomas (ESCCs).Multi-omics analysis led to the classification of ESCCs into four subtypes: cell cyclepathway activation, NRF2 oncogenic activation, immune suppression (IS), and immunemodulation (IM). IS and IM cases were highly immune infiltrated but differed in thetype and distribution of immune cells. IM cases showed better response to immune checkpointblockade therapy than other subtypes in a clinical trial. We further developed a classifierwith 28 features to identify the IM subtype, which predicted anti-PD-1 therapy responsewith 85.7% sensitivity and 90% specificity. These results emphasize the clinical valueof unbiased molecular classification based on multi-omics data and have the potentialto further improve the understanding and treatment of ESCC.

DOI: 10.1016/j.ccell.2022.12.004

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00590-6