近日,美国国立卫生研究院Geoffrey Schoenbaum等研究人员合作发现外侧眶额皮层在创建认知地图中的作用
Title: The role of the lateral orbitofrontal cortex in creating cognitive maps
Author: Costa, Kau Machado, Scholz, Robert, Lloyd, Kevin, Moreno-Castilla, Perla, Gardner, Matthew P. H., Dayan, Peter, Schoenbaum, Geoffrey
Issue&Volume: 2022-12-22
Abstract: We use mental models of the world—cognitive maps—to guide behavior. The lateral orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps to simulate outcomes, but recent evidence suggests that it may instead support behavior by underlying map creation. We tested between these two alternatives using outcome-specific devaluation and a high-potency chemogenetic approach. Selectively inactivating lOFC principal neurons when male rats learned distinct cue–outcome associations, but before outcome devaluation, disrupted subsequent inference, confirming a role for the lOFC in creating new maps. However, lOFC inactivation surprisingly led to generalized devaluation, a result that is inconsistent with a complete mapping failure. Using a reinforcement learning framework, we show that this effect is best explained by a circumscribed deficit in credit assignment precision during map construction, suggesting that the lOFC has a selective role in defining the specificity of associations that comprise cognitive maps.
DOI: 10.1038/s41593-022-01216-0
Source: https://www.nature.com/articles/s41593-022-01216-0
Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:28.771
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex